Priyadarshini Kachroo, Ph.D.
Dr. Kachroo’s lab develops computational methods to identify clinically relevant multi-omic biomarkers with a focus on primordial prevention central to respiratory disease outcomes and other complex age-associated inflammatory diseases.
Her long-term goal is to examine the most complete molecular profile of disease development through multi-omic integration and gain insights into gene-environment interactions across life-course.
Her current focus is to identify integrative genetic, epigenetic and metabolomic biomarkers, gene-drug targets and inflammatory pathways predictive of lung function decline in children with asthma by using machine learning and network methods.
Keywords: epigenomics, metabolomics, transcriptomics, multi-omic integration, precision medicine, translational data analytics, drug repurposing, inflammation, in-utero smoke exposure, respiratory diseases, asthma, COPD, and related health outcomes, epigenetic aging
Title: Methylomic and metabolomic determinants of Lung Function in Asthmatics
Sponsor Agency: NIH/NHLBI
Brief Overview of Aims:
Aim 1: Genome-methylome-metabolome integration in association with lung function
Aim 2: Integrative omic-driven networks and pathways for lung function
The proposed study aims to identify predictive multi-omic biomarkers for lung function outcomes to elucidate the mediating role of genetic variants, metabolites and DNA-methylation CpGs in association with lung function decline during early life and adolescence in the context of asthma.
Total Dollar Amount: Year 1-$172,800; Year 2-$172,800; Year 3/4/5-up to $249,000 per year
Funding Period: 04/2022-06/2027
Selected Publications
- Recto K, Kachroo P*, Huan T, Van Den Berg D, Lee GY, Bui H, Lee DH, Gereige J, Yao C, Hwang SJ, Joehanes R, Weiss ST; NHLBI Trans-Omics in Precision Medicine (TOPMed) Consortium; O’Connor GT, Levy D, DeMeo DL. Epigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma. EBioMedicine. 2023 Sep;95:104758. doi: 10.1016/j.ebiom.2023.104758. Epub 2023 Aug 18. PMID: 37598461; PMCID: PMC10462855.
- Kachroo P*, Stewart ID*, Kelly RS, Stav M, Mendez K, Dahlin A, Soeteman DI, Chu SH, Huang M, Cote M, Knihtilä HM, Lee-Sarwar K, McGeachie M, Wang A, Wu AC, Virkud Y, Zhang P, Wareham NJ, Karlson EW, Wheelock CE, Clish C, Weiss ST, Langenberg C, Lasky-Su JA. Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma. Nat Med. 2022 Apr;28(4):814-822. doi: 10.1038/s41591-022-01714-5. Epub 2022 Mar 21. Erratum in: Nat Med. 2022 Aug;28(8):1723. doi: 10.1038/s41591-022-01949-2. PMID: 35314841; PMCID: PMC9350737.
- Kachroo P, Morrow JD, Vyhlidal CA, Gaedigk R, Silverman EK, Weiss ST, Tantisira KG, DeMeo DL. DNA methylation perturbations may link altered development and aging in the lung. Aging (Albany NY). 2021 Jan 19;13(2):1742-1764. doi: 10.18632/aging.202544. Epub 2021 Jan 19. PMID: 33468710; PMCID: PMC7880367.
- Kachroo P, Morrow JD, Kho AT, Vyhlidal CA, Silverman EK, Weiss ST, Tantisira KG, DeMeo DL. Co-methylation analysis in lung tissue identifies pathways for fetal origins of COPD. Eur Respir J. 2020 Oct 29;56(4):1902347. doi: 10.1183/13993003.02347-2019. PMID: 32482784; PMCID: PMC8087182.
- Kachroo P, Hecker J*, Chawes BL*, Ahluwalia TS, Cho MH, Qiao D, Kelly RS, Chu SH, Virkud YV, Huang M, Barnes KC, Burchard EG, Eng C, Hu D, Celedón JC, Daya M, Levin AM, Gui H, Williams LK, Forno E, Mak ACY, Avila L, Soto-Quiros ME, Cloutier MM, Acosta-Pérez E, Canino G, Bønnelykke K, Bisgaard H, Raby BA, Lange C, Weiss ST, Lasky-Su JA; National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Consortium. Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma. Chest. 2019 Dec;156(6):1068-1079. doi: 10.1016/j.chest.2019.08.2202. Epub 2019 Sep 23. PMID: 31557467; PMCID: PMC6904857.
Complete List of Published Work in MyBibliography.
- Poster Presentation Award, Symposium on Incorporating Sex and Gender Into Research, Brigham Research Institute (BRI), Brigham and Women’s Hospital and Harvard Medical School (BWH and HMS), Boston, MA
2022
- Chair’s Research Award, Department of Medicine, BWH and HMS
- Research Excellence Award, Poster presentation at the Discover Brigham (BRI) at BWH (in person)
2021
- Early Career Award in the best abstract category submitted by any postdoc, Early Career Members Network Society, 17th Annual Metabolomics Society Conference (poster presentation, held online)
2020
- Abstract Scholarship Award, Assembly on Environmental, Occupational and Population Health, American Thoracic Society International Conference, Philadelphia, CA, USA (Rapid Poster, held online)
2018
- Abstract Scholarship Award, Assembly on Environmental, Occupational and Population Health, American Thoracic Society International Conference, San Francisco, CA, USA (Oral Presentation)
- Appreciation for outstanding contribution to the BWH Postdoctoral Leadership Council, BRI, Brigham Health
2015
- International exchange (Two weeks), CeMM, Research Center for Molecular Medicine, Vienna, Austria
2014
- RISE-DAAD Fellowship (12 weeks), German Academic Exchange Service
2010-2012
- Erasmus Mundus Fellowship (€22,000), India4EU, University of Bologna, Italy
Please reach out to Dr. Priyadarshini Kachroo at Priyadarshini.kachroo@rutgers.edu if you are interested to learn more about her research or join her team to get involved in projects.
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