Study Eligibility

Inclusion Criteria: To be eligible for to participate in this study, all potential participants must:

• Be assigned as either a biological female or male and identify as such
• Meet current DSM V criteria for moderate to severe AUD
• Be ≥ 18 years old and have a body mass index (BMI) of 18-35
• Express a desire to quit alcohol as determined by the SOCRATES scale
• Demonstrate a positive urine for alcohol on admission to study procedures
• Be able to provide informed verbal and written consent
• Be able to read English and complete study evaluations
• Be in good health as verified by the intake 1 physical examination

Exclusion criteria: You are not eligible to participate in this study if you:

• Meet criteria for moderate to severe SUD, excluding alcohol and nicotine
• A positive screen for substances of abuse, excluding alcohol and nicotine
• Being psychotic or otherwise severely psychiatrically disabled (including suicidal, homicidal, current mania)
• Meet criteria for physiological dependence on alcohol requiring medical detoxification
• Regular use of medications in the last 6 months (with the exception of stabilization on SSRIs) that, in the opinion of the site physician may be contraindicated with GXR and be potentially harmful to the participant,
• Are pregnant or breast feeding
• Are vii) be using monophasic contraceptives
• Have cardiovascular disease including high blood pressure
• Have bradycardia with sitting heart rate (HR) <60 bpm
• Show EKG evidence of any clinically significant conduction abnormalities, including a Bazett’s QTc of >470 msec for women and Bazett’s QTc of >450 msec for men.

All information will be kept confidential.

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