Priyadarshini Kachroo, Ph.D.
Dr. Kachroo’s lab develops computational methods to identify clinically relevant multi-omic biomarkers with a focus on primordial prevention central to respiratory disease outcomes and other complex age-associated inflammatory diseases. Her long-term goal is to examine the most complete molecular profile of disease development through multi-omic integration and gain insights into gene-environment interactions across life-course.
Research Overview
Advancing Lung Health Through Precision Medicine
Lung resilience is a marker of healthy longevity making them inherently interlinked and involving several complex biochemical processes reflected in omics. Taking a life course approach, Dr. Kachroo has led various studies to establish early-life molecular origins of respiratory diseases including asthma and adult lung disease.
Her current focus is to identify integrative genetic, epigenetic and metabolomic biomarkers, gene-drug targets and inflammatory pathways predictive of lung function decline in children with asthma by using machine learning and network methods.
Funding & Grants
Supported Research Programs
Federal, foundation, and institutional funding advancing predictive modeling of treatment responses
NIH/NHLBI
$249,000
Methylomic and metabolomic determinants of Lung Function in Asthmatics
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Brief Overview of Aims:
Aim 1: Genome-methylome-metabolome integration in association with lung function
Aim 2: Integrative omic-driven networks and pathways for lung function
The proposed study aims to identify predictive multi-omic biomarkers for lung function outcomes to elucidate the mediating role of genetic variants, metabolites and DNA-methylation CpGs in association with lung function decline during early life and adolescence in the context of asthma.
Total Dollar Amount: Year 1-$172,800; Year 2-$172,800; Year 3/4/5-up to $249,000 per year
Funding Period: 04/2022-06/2027
- 04/2022-06/2027
Publications & Impact
Selected Research Publications
2023
Epigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma
Recto K, Kachroo P*, Huan T, Van Den Berg D, Lee GY, Bui H, Lee DH, Gereige J, Yao C, Hwang SJ, Joehanes R, Weiss ST; NHLBI Trans-Omics in Precision Medicine (TOPMed) Consortium; O’Connor GT, Levy D, DeMeo DL.
EBioMedicine. 2023 Sep;95:104758. doi: 10.1016/j.ebiom.2023.104758. Epub 2023 Aug 18. PMID: 37598461; PMCID: PMC10462855
2022
Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma
Kachroo P*, Stewart ID*, Kelly RS, Stav M, Mendez K, Dahlin A, Soeteman DI, Chu SH, Huang M, Cote M, Knihtilä HM, Lee-Sarwar K, McGeachie M, Wang A, Wu AC, Virkud Y, Zhang P, Wareham NJ, Karlson EW, Wheelock CE, Clish C, Weiss ST, Langenberg C, Lasky-Su JA.
Nat Med. 2022 Apr;28(4):814-822. doi: 10.1038/s41591-022-01714-5. Epub 2022 Mar 21. Erratum in: Nat Med. 2022 Aug;28(8):1723. doi: 10.1038/s41591-022-01949-2. PMID: 35314841; PMCID: PMC9350737
2021
DNA methylation perturbations may link altered development and aging in the lung
Kachroo P, Morrow JD, Vyhlidal CA, Gaedigk R, Silverman EK, Weiss ST, Tantisira KG, DeMeo DL.
Aging (Albany NY). 2021 Jan 19;13(2):1742-1764. doi: 10.18632/aging.202544. Epub 2021 Jan 19. PMID: 33468710; PMCID: PMC7880367
2020
Co-methylation analysis in lung tissue identifies pathways for fetal origins of COPD
Kachroo P, Morrow JD, Kho AT, Vyhlidal CA, Silverman EK, Weiss ST, Tantisira KG, DeMeo DL.
Eur Respir J. 2020 Oct 29;56(4):1902347. doi: 10.1183/13993003.02347-2019. PMID: 32482784; PMCID: PMC8087182
2019
Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma
Kachroo P, Hecker J*, Chawes BL*, Ahluwalia TS, Cho MH, Qiao D, Kelly RS, Chu SH, Virkud YV, Huang M, Barnes KC, Burchard EG, Eng C, Hu D, Celedón JC, Daya M, Levin AM, Gui H, Williams LK, Forno E, Mak ACY, Avila L, Soto-Quiros ME, Cloutier MM, Acosta-Pérez E, Canino G, Bønnelykke K, Bisgaard H, Raby BA, Lange C, Weiss ST, Lasky-Su JA; National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Consortium
Chest. 2019 Dec;156(6):1068-1079. doi: 10.1016/j.chest.2019.08.2202. Epub 2019 Sep 23. PMID: 31557467; PMCID: PMC6904857.
Achievements
Awards & Honors
2023
Poster Presentation Award, Symposium on Incorporating Sex and Gender Into Research, Brigham Research Institute (BRI), Brigham and Women’s Hospital and Harvard Medical School (BWH and HMS), Boston, MA
2022
Chair’s Research Award, Department of Medicine, BWH and HMS
Research Excellence Award, Poster presentation at the Discover Brigham (BRI) at BWH (in person)
2021
Early Career Award in the best abstract category submitted by any postdoc, Early Career Members Network Society, 17th Annual Metabolomics Society Conference (poster presentation, held online)
2020
Abstract Scholarship Award, Assembly on Environmental, Occupational and Population Health, American Thoracic Society International Conference, Philadelphia, CA, USA (Rapid Poster, held online)
2018
Abstract Scholarship Award, Assembly on Environmental, Occupational and Population Health, American Thoracic Society International Conference, San Francisco, CA, USA (Oral Presentation)
Appreciation for outstanding contribution to the BWH Postdoctoral Leadership Council, BRI, Brigham Health
2015
International exchange (Two weeks), CeMM, Research Center for Molecular Medicine, Vienna, Austria
2014
RISE-DAAD Fellowship (12 weeks), German Academic Exchange Service
2010-2012
Erasmus Mundus Fellowship (€22,000), India4EU, University of Bologna, Italy
Get Involved
Join our Research
Interested in advancing your research? Reach out to Dr. Kachroo
to learn more about opportunities to get involved.
